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BITS2007 Meeting
BITS2007 Meeting



26-28 April 2007 Napoli, Italy

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Huntington's Disease: From Experimental Results to Interaction Networks, Patho-Pathway Construction and Disease Hypothesis
 
Motivation
Protein-protein interaction networks and mechanistic pathway models are excellent
tools in the drug discovery process. They can be used to identify and select highly
reliable targets for a given disease hypothesis. Combining information from diverse
sources, like in house experiments as well as literature, allows further development
of interaction networks into detailed descriptions of cellular pathways. Under their
interactive form, pathway diagrams can integrate all relevant data regarding a
project into one framework by linking the different data sources.


Methods
Siena Biotech is a drug discovery company committed to understanding and treating
human neurodegenerative and neuroproliferative diseases, including rare disorders
like Huntington's Disease (HD). We use interaction networks analysis and pathway
design tools to support target identification and validation activities. Experimental
results (e.g. from differential proteomics experiments) are incorporated in protein
interaction networks, analyzed and further developed into biomolecular patho-pathways
including literature findings to give rise to an improved understanding of the
underlying modulation mechanisms. The pathway diagrams are also used as communication
tools, particularly for our interdisciplinary project teams, thus ensuring a common
understanding and facilitating critical interrogations about disease hypotheses or
mode of actions.


Results
Here we present the experimental results analysis and ongoing construction of a HD
patho-pathway and discuss mechanistic disease hypothesis inferred from this internal
effort.
 
Id: 155
Place: Napoli, Italy
Centro Congressi "Federico II"
Via Partenope 36
Napoli
Starting date:
-- not yet scheduled --   
Duration: 01h00'
Contribution type: Poster
Primary Authors: KREMER, Andreas (Siena Biotech S.p.A., Discovery Research, Siena, Italy)
Co-Authors: E. GONZALEZ, Couto (Siena Biotech S.p.A., Discovery Research, Siena, Italy)
S., Gotta (Siena Biotech S.p.A., Discovery Research, Siena, Italy)
F., Heitz (Siena Biotech S.p.A., Discovery Research, Siena, Italy)
L., Magnoni (Siena Biotech S.p.A., Discovery Research, Siena, Italy)
S., Matteoni (Siena Biotech S.p.A., Discovery Research, Siena, Italy)
R., Raggiaschi (Siena Biotech S.p.A., Discovery Research, Siena, Italy)
AND G.C., Terstappen (Siena Biotech S.p.A., Discovery Research, Siena, Italy)
Presenters: KREMER, Andreas
 
Included in session: Poster Session
Included in track: Biomedical informatics
 




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